Experimental design and modelling approach to evaluate efficacy of β-lactam/β-lactamase inhibitor combinations
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a comparison of teachers and supervisors, with respect to teacher efficacy and reflection
supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...
15 صفحه اولA retrospective study to evaluate the efficacy of a new antibiotic adjuvant entity (β-lactam/β-lactamase inhibitor/adjuvant disodium edetate combination) for management of sepsis
Aim and objective: The management of patients with sepsis and septic shock requires an integrated approach of accurate diagnosis along with rapid initiation of appropriate antimicrobial therapy. Here we present a retrospective analysis of a new therapy opted and outcome of the patients suffering from gram negative bacterial sepsis. Materials and methods: A retrospective study was conducted to e...
متن کاملCombinatorial Pharmacodynamics of Ceftolozane-Tazobactam against Genotypically Defined β-Lactamase-Producing Escherichia coli: Insights into the Pharmacokinetics/Pharmacodynamics of β-Lactam-β-Lactamase Inhibitor Combinations.
Despite a dearth of new agents currently being developed to combat multidrug-resistant Gram-negative pathogens, the combination of ceftolozane and tazobactam was recently approved by the Food and Drug Administration to treat complicated intra-abdominal and urinary tract infections. To characterize the activity of the combination product, time-kill studies were conducted against 4 strains ofEsch...
متن کاملComparative Evaluation of the in-vitro Activity of Six β-lactam/β-lactamase Inhibitor Combinations against Gram Negative Bacilli.
BACKGROUND The extensive use of the β-lactam antibiotics in hospitals and in the community has created major resistance problems which has led to increased morbidity, mortality and healthcare costs. The use of the β-lactamase inhibitors in combination with the β-lactam antibiotics is currently the most successful strategy used for circumventing the resistance mechanisms. OBJECTIVE To evaluate...
متن کاملClinical efficacy of β-lactam/β-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum β-lactamase-producing Enterobacteriaceae in haematological patients with neutropaenia: a study protocol for a retrospective observational study (BICAR)
INTRODUCTION Bloodstream infection (BSI) due to extended-spectrum β-lactamase-producing Gram-negative bacilli (ESBL-GNB) is increasing at an alarming pace worldwide. Although β-lactam/β-lactamase inhibitor (BLBLI) combinations have been suggested as an alternative to carbapenems for the treatment of BSI due to these resistant organisms in the general population, their usefulness for the treatme...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2018
ISSN: 1198-743X
DOI: 10.1016/j.cmi.2017.07.020